Preclinical research has demonstrated that specific nutrients support synapse formation, with the greatest effects observed when these nutrients are used in combination
Preclinical research providing the scientific rationalE behind Souvenaid
The scientific rationale behind the mechanism of action of Souvenaid is based on the ability of specific nutrients to support neuronal membrane synthesis and synapse formation, leading to the hypothesis that combinations of these nutrients could provide clinically relevant benefits to early Alzheimer’s disease patients.
The development of Souvenaid is the result of over 10 years of research. Preclinical work conducted by scientists at the Massachusetts Institute of Technology (MIT) formed the basis for our clinical research programme [1-20].
Nutrients and Synapse Formation
Nutrients working together to support synapse formation
Preclinical research demonstrates that enhancing the diet with key nutrients increases brain dendritic spines, synaptic proteins and neurite outgrowth, all of which are prerequisites for brain synapse formation [7,9,21]. In vitro studies have shown that uridine, B vitamins, choline and omega-3 fatty acids increase phospholipid synthesis, and promote neurite outgrowth [5,9,22-24].
The greatest benefits on synapse formation are observed when specific nutrients are used in combination [5-7]. The combination of UMP and DHA was shown to increase levels of brain phospholipids, dendritic spine density and synaptic proteins in in vitro studies [5-7]. In animal models, the combination of uridine and choline has been shown to improve learning and memory .
Collectively, this preclinical research supports the mechanism of action of Souvenaid. By providing the specific nutrients required for key processes involved in synapse formation , Souvenaid can improve memory in patients with early Alzheimer’s disease, as demonstrated by the results of the Souvenaid clinical trial programme [26,27].
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- Scheltens P, et al.Efficacy of Souvenaid in mild Alzheimer’s disease: results from a randomized, controlled trial. J Alzheimer’s Dis. 2012;31:225–236.