Memory loss in Alzheimer’s Disease

Memory loss is an early symptom in the progression of Alzheimer’s disease which has major consequences on activities of daily living (ADL).

Memory loss

Memory loss is one of the first Alzheimer’s disease symptoms

Memory loss is one of the first Alzheimer’s disease symptoms to develop, and is a key indicator of the cognitive decline associated with the disease [1-3]. Memory lapses range from frustrating (e.g. lost keys) to dangerous (e.g. stove left on), and can have major consequences on the patient’s quality of life [4]. As a result, patients can have decreased involvement in daily life and routine activities, leading to loss of autonomy and increased dependence on carers [4-6]. The loss of memory is closely linked to synapse loss. [7-9].

 

References

  1. Feldman H and Gracon S. In: Gauthier S, ed. Clinical Diagnosis and Management of Alzheimer‘s Disease. Martin Dunitz: London; 1996:239-259.
  2. Welsh KA, et al. A detection and staging of dementia in Alzheimer’s disease. Use of neuropsychological measure developed for the Consortium to Establish a Registry for Alzheimer’s disease. Arch Neurol. 1992;49:448-452.
  3. Galasko D. An integrated approach to the management of Alzheimer’s disease: assessing cognition, function and behaviour. Eur J Neurol. 1998;5(suppl 4):S9–17.
  4. Gold CA and Budson AE. Memory loss in Alzheimer’s disease: implications for development of therapeutics. Expert Rev. Neurother. 2008; 8:1879-1891
  5. Sarazin M, et al. Neuropsychological predictors of dependency in patients with Alzheimer’s disease. Neurology. 2005;64:1027-31.
  6. Amieva H, et al. Prodromal Alzheimer’s disease: progressive emergence of the clinical symptoms. Ann Neurol .2008;64:492-8.
  7. Terry RD. Alzheimer’s disease and the aging brain. J Geriatr Psychiatry Neurol. 2006;19:125-128.
  8. Scheff SW, et al. Hippocampal synaptic loss in early Alzheimer’s disease and mild cognitive impairment. Neurobiol Aging. 2006;27:1372-1384.
  9. Sperling RA, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7:280-292.